Fig. 4.
ApoE, APP, and PrPC immunoreactivity of the coarse-grained plaque compared to the cotton wool and classic cored plaque. a ApoE was abundantly present all through the coarse-grained plaque. b Dystrophic neurites immunoreactive for APP were found throughout the coarse-grained plaque. c The coarse-grained plaque was immunoreactive for PrPC. d The cotton wool plaque stained positive for ApoE. e APP dystrophic neurites were negligibly visible in the cotton wool plaques. f PrPC was observed in cotton wool plaques. g ApoE was found in both the corona and core of the classic cored plaque. ApoE staining intensity was highest in the core. h APP dystrophic neurites could be seen surrounding the core of classic cored plaques. i The classic cored plaque was immunoreactive for PrPC. APOE genotype of the respective case is shown in right lower corner of images of plaques stained for ApoE. Scale bar represents 50 µm and is applicable to all images. ApoE apolipoprotein E, APP amyloid precursor protein, PrPC cellular prion protein