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. 2020 Sep 14;140(6):811–830. doi: 10.1007/s00401-020-02198-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Immunofluorescence for Aβ₄₀ and Aβ₄₂ in the coarse-grained plaque compared to CAA-Type 1 and the classic cored plaque. a–c Double immunofluorescence labeling for Aβ₄₀ (green) and Aβ₄₂ (red) confirmed the Aβ₄₀ predominance in coarse-grained plaques. c White arrowhead indicates an Aβ₄₀ tubular-like structure filled with Aβ₄₂. d–f CAA-Type 1 showed a similar Aβ₄₀ to Aβ₄₂ ratio as the coarse-grained plaque. g–i Classic cored plaques were predominantly Aβ₄₂ immunoreactive. Scale bar represents 50 µm and is applicable to all images. Aβ₄₀ amyloid-beta 40, Aβ₄₂ amyloid-beta 42, CAA cerebral amyloid angiopathy