Fig. 8.

Vascular association of the coarse-grained plaque compared to the cotton wool and classic cored plaque. a–d Coarse-grained plaque showed immunoreactivity for Aβ₄₀, norrin, and laminin but not for collagen IV. e–h Although the cotton wool plaque was positive for the same markers, staining morphology differed compared to the coarse-grained plaque. i–l Classic cored plaque has an Aβ₄₀ positive core, was not immunoreactive for norrin, and showed a punctate staining for both laminin and collagen IV. Scale bar represents 50 µm and is applicable to all images. Aβ₄₀ amyloid-beta 40