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. 2020 Sep 14;140(6):811–830. doi: 10.1007/s00401-020-02198-8

Fig. 9.

Fig. 9

3D composition of Aβ40 and Aβ42 in the coarse-grained plaque. CLSM 3D image of two coarse-grained plaques stained for Aβ40 (a; green) and Aβ42 (b; red) with Aβ40/Aβ42 overlay in c, is shown. In the smaller coarse-grained plaque (upper plaque) Aβ40 and Aβ42 is co-localized. In the larger coarse-grained plaques (lower plaque) Aβ40 showed an outer shell structure, surrounding the lesser present Aβ42. White cross in XY indicates the same point in space as the white cross in XZ and YZ. Scale bar represents 10 µm and is applicable to all images. 40 amyloid-beta 40, 42 amyloid-beta 42, CLSM confocal laser scanning microscopy