Table 2.

– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal mucosa.

	Grupo 1		Grupo 2		Grupo 3
Mediadores	N	%	N	%	N	%	p
IL-1	53	51,0	24	54,2	44	28,6	0,069
PGE2	27	55,1	15	75,0	12	34,3	0,013* G1 = G2 > G3
CD8	37	80,4	18	78,3	21	80,8	1000
TNFα	25	55,6	5	20,8	12	42,9	0,021 G1 > G2
Synaptophysin	33	73,3	12	50,0	28	53,6	0,093
Enolase	35	76,1	18	78,3	22	84,6	0,761*
S-100 protein	34	73,9	16	66,7	22	81,5	0,481
PGP-9.5	20	42,6	0	0,0	1	2,7	< 0,001* G1 > (G2 = G3)
Tryptase	43	89,6	12	52,2	12	32,4	< 0,001 G1 > (G2 = G3)
VIP	38	79,2	18	81,8	20	83,3	0,942*
GIP	35	81,4	12	60,0	23	82,1	0,149*
VEGF	35	72,9	19	90,5	20	83,3	0,254*

N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.

Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.

Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.

Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.

GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.

p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.