TABLE 3.

– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal submucosa.

	Grupo 1		Grupo 2		Grupo 3
Mediadores	N	%	N	%	N	%	p
IL-1	53	4,1	24	16,7	44	5,7	0,168*
PGE2	5	10,2	8	40,0	8	22,9	0,020* G2 > (G1 = G3)
CD8	35	76,1	18	78,3	18	69,2	0,736
TNFα	13	28,9	3	12,5	4	14,3	0,200*
Synaptophysin	10	22,2	4	16,7	6	21,4	0,899*
Enolase	26	56,5	13	56,5	13	50,0	0,850
S-100 protein	33	71,7	12	50,0	15	55,6	0,150
PGP-9.5	2	4,3	0	0,0	0	0,0	0,693*
Tryptase	42	87,5	12	52,2	8	21,6	< 0,001 G1 > G2 > G3
VIP	0	0,0	0	0,0	7	29,2	< 0,001* G3 > (G1 = G2)
GIP	27	62,8	11	55,0	10	35,7	0,080
VEGF	3	6,3	3	14,3	2	8,3	0,554*

N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.

Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.

Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.

Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.

GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.

p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.