TABLE 4.
– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal submucosa nerve plexus.
| Grupo 1 |
Grupo 2 |
Grupo 3 |
|||||
|---|---|---|---|---|---|---|---|
| Mediadores | N | % | N | % | N | % | p |
| IL-1 | 53 | 0,0 | 24 | 0,0 | 44 | 0,0 | – |
| PGE2 | 4 | 8,2 | 2 | 10,0 | 8 | 22,9 | 0,165* |
| CD8 | 0 | 0,0 | 1 | 4,3 | 4 | 15,4 |
0,012* G3 > G1 |
| TNFα | – | – | – | – | – | – | – |
| Synaptophysin | 12 | 26,7 | 4 | 16,7 | 12 | 42,9 | 0,105 |
| Enolase | 27 | 57,7 | 16 | 69,6 | 18 | 69,2 | 0,554 |
| S-100 protein | 34 | 73,9 | 12 | 50,0 | 21 | 77,8 | 0,062 |
| PGP-9.5 | 33 | 70,2 | 3 | 13,0 | 3 | 8,1 |
< 0,001* G1 > (G2 = G3) |
| Tryptase | 1 | 2,1 | 0 | 0,0 | 1 | 2,7 | 1000* |
| VIP | 33 | 68,8 | 18 | 81,8 | 13 | 54,2 | 0,131 |
| GIP | – | – | – | – | – | – | – |
| VEGF | 30 | 62,5 | 18 | 85,7 | 13 | 54,2 | 0,069 |
N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.
Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.
GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of.vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.
p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.