TABLE 5.
– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal muscle layer.
| Grupo 1 |
Grupo 2 |
Grupo 3 |
|||||
|---|---|---|---|---|---|---|---|
| Mediadores | N | % | N | % | N | % | p |
| IL-1 | 53 | 6,1 | 24 | 12,5 | 44 | 2,9 | 0,319* |
| PGE2 | 4 | 8,2 | 3 | 15,0 | 5 | 14,3 | 0,559* |
| CD8 | 4 | 8,7 | 9 | 39,1 | 7 | 26,9 | 0,008* - (G2 = G3) > G1 |
| TNFα | – | – | – | – | – | – | – |
| Synaptophysin | 22 | 48,9 | 4 | 16,7 | 6 | 21,4 | 0,008 - G1 > (G2 = G3) |
| Enolase | 30 | 65,2 | 3 | 13,0 | 16 | 61,5 | < 0,001 - (G1 = G3) > G2 |
| S-100 protein | 32 | 69,6 | 13 | 54,2 | 13 | 48,1 | 0,160 |
| PGP-9.5 | 18 | 38,3 | 1 | 4,3 | 2 | 5,4 | < 0,001* - G1 > (G2 = G3) |
| Tryptase | 37 | 77,1 | 12 | 52,2 | 3 | 8,1 | < 0,001 - G1 > G2 > G3 |
| VIP | 3 | 6,3 | 0 | 0,0 | 9 | 37,5 | < 0,001* - G3 > (G1 = G2) |
| GIP | 3 | 7,0 | 2 | 10,0 | 4 | 14,3 | 0,601* |
| VEGF | 5 | 10,4 | 2 | 9,5 | 8 | 33,3 | 0,046* - (G1 = G2) > G3 |
N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.
Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.
GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.
p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.