TABLE 6.
– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal myenteric plexus.
| Grupo 1 |
Grupo 2 |
Grupo 3 |
|||||
|---|---|---|---|---|---|---|---|
| Mediadores | N | % | N | % | N | % | p |
| IL-1 | 12 | 24,5 | 11 | 45,8 | 5 | 14,3 |
0,024 G2 > (G1 = G3) |
| PGE2 | 15 | 30,6 | 13 | 65,0 | 11 | 31,4 |
0,018 G2 > (G1 = G3) |
| CD8 | 0 | 0,0 | 1 | 4,3 | 1 | 3,8 | 0,263* |
| TNFα | – | – | – | – | – | – | – |
| Synaptophysin | 37 | 82,2 | 21 | 87,5 | 21 | 75,0 | 0,526 |
| Enolase | 36 | 78,3 | 21 | 91,3 | 19 | 73,1 | 0,253* |
| S-100 protein | 37 | 80,4 | 21 | 87,5 | 20 | 74,1 | 0,481* |
| PGP-9.5 | 39 | 83,0 | 12 | 52,2 | 4 | 10,8 |
< 0,001 G1 > G2 > G3 |
| Tryptase | 4 | 8,3 | 0 | 0,0 | 1 | 2,7 | 0,287* |
| VIP | 41 | 85,4 | 19 | 86,4 | 16 | 66,7 | 0,154* |
| GIP | – | – | – | – | – | – | – |
| VEGF | 40 | 83,3 | 18 | 85,7 | 16 | 66,7 | 0,212 |
N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.
Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.
GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.
p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.