TABLE 7.
– Comparison between the three studied groups regarding the percentage of positive immunohistochemical expression of all antibodies in the appendiceal serosa.
| Group 1 |
Group 2 |
Group 3 |
|||||
|---|---|---|---|---|---|---|---|
| Mediators | N | % | N | % | N | % | p |
| IL-1 | 53 | 0,0 | 24 | 0,0 | 44 | 0,0 | – |
| PGE2 | 1 | 2,0 | 1 | 5,0 | 3 | 8,6 | 0,339* |
| CD8 | 2 | 4,3 | 7 | 30,4 | 2 | 7,7 |
0,006* G2 > (G1 = G3) |
| TNFα | 0 | 0,0 | 3 | 12,5 | 1 | 3,6 |
0,025* G2 > G1 |
| Synaptophysin | 1 | 2,2 | 0 | 0,0 | 0 | 0,0 | 1000 |
| Enolase | 0 | 0,0 | 1 | 4,3 | 0 | 0,0 | 0,242* |
| S-100 protein | 3 | 6,5 | 6 | 25,0 | 3 | 11,1 | 0,098* |
| PGP-9.5 | 0 | 0,0 | 0 | 0,0 | 0 | 0,0 | – |
| Tryptase | 4 | 8,3 | 4 | 17,4 | 4 | 10,8 | 0,493* |
| VIP | 0 | 0,0 | 0 | 0,0 | 0 | 0,0 | – |
| GIP | – | – | – | – | – | – | – |
| VEGF | 35 | 72,9 | 19 | 90,5 | 20 | 83,3 | 0,254* |
N: Total appendices; %: Percentage of positive immunohistochemical expression for each antibody, indicating the presence of its corresponding mediator.
Group 1 (G1): macro- and microscopic normal appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 2 (G2): inflamed appendices of patients with clinical and complementary diagnostic exams of acute appendicitis.
Group 3 (G3): normal appendices of patients with ascending colon adenocarcinoma submitted to right colectomy.
GIP: gastrin inhibitor peptide; Tryptase: mast cell-related tryptase, VEGF: growth factor of vascular endothelium; VIP: intestinal vasoactive peptide; TNFα: tumor necrosis factor alpha; IL-1: interleukin 1; PGE2:prostaglandin E2; PGP 9.5: gene-protein product 9.5; CD8: CD8 T lymphocytes.
p: significance by Pearson's chi-square test; *: significance by Fisher's exact test.