Table 1.

miR-21 and p53 mRNA Levels in NSCLC Tissue Samples

Variables	n	miR-21 Level (2−ΔΔCt Value)	p Value	p53 Level (2−ΔΔCt Value)	p Value
Tumor versus Normal
NSCLC	200	18.04 ± 2.09	0.0001	5.81 ± 1.05	0.02
Normal tissues	200	1.23 ± 0.16		1.14 ± 0.12
Histology
Adenocarcinoma	142	19.15 ± 1.62	0.03	7.76 ± 1.14	0.032
SCC	58	14.93 ± 1.21		4.92 ± 0.99
Sex
Male	116	16.02 ± 2.01	0.58	5.61 ± 1.03	0.63
Female	84	19.25 ± 2.59		7.89 ± 1.25
History of Smoking
Ever	113	19.36 ± 2.51	0.65	7.42 ± 1.12	0.021
Never	87	17.99 ± 2.07		4.98 ± 1.05
Tumor Size (cm)
T1 (>3)	79	23.36 ± 2.61	0.04	8.12 ± 1.52	0.031
T1 (0–3)	121	16.46 ± 2.01		3.92 ± 1.07
Distant Metastasis
Yes	46	24.38 ± 2.63	0.01	10.52 ± 1.52	0.013
No	154	13.89 ± 1.81		2.89 ± 0.98
Stage
I	64	11.02 ± 1.89		2.98 ± 0.54
II	51	16.25 ± 2.32		4.77 ± 0.78
III	44	21.28 ± 2.67		6.59 ± 1.03
IV	39	24.65 ± 2.98		8.43 ± 1.12
TNM Stage
I and II			0.001		0.001
III and IV
Tumor (T)
T1	53	10.99 ± 1.56		3.18 ± 0.59
T2	52	17.02 ± 2.42		4.76 ± 0.62
T3	49	21.98 ± 2.81		7.59 ± 1.16
T4	46	25.85 ± 3.12		8.43 ± 1.23
T Stage
T1 and T2			0.003		0.02
T3 and T4
Lymph Node Metastasis (N)
N0	72	11.29 ± 1.66		2.88 ± 0.55
N1	49	18.12 ± 2.62		3.75 ± 0.63
N2	45	21.18 ± 2.51		6.52 ± 0.73
N3	34	24.77 ± 3.02		8.46 ± 1.52
N Stage
N0 and N1			0.01		0.02
N2 and N3

SCC, squamous cell carcinoma.