Table 3.
p53 Mutation Type, Site, and Specific Distribution in 100 NSCLC Patients
| No. | Exon | Base Variation | Amino Acid Variation |
|---|---|---|---|
| 1 | 8 | c.797G>A | p.G266E |
| 2 | 8 | c.907dupT | p.P301fs |
| 3 | 5 | c.527G>T | p.R273H |
| 4 | 7 | c.746A>T | p.R249W |
| 6 | 5 | c.657G>A | p.R175H |
| 7 | 8 | c.817C>T | p.R273C |
| 8 | 5 | c.564G>C | p.R175H |
| 9 | 6 | c.577C>T | p.H193Y |
| 10 | 5 | c.848G>T | p.G245S |
| 11 | 6 | c.524G>A | p.R175H |
| 14 | 5 | c.382C>A | p.P128T |
| 15 | 7 | c.607C>G | p.R282W |
| 16 | 8 | c.844C>T | p.R248Q |
| 17 | 6 | c.584T>C | p.I195T |
| 18 | 5 | c.700T>C | p.Y234H |
| 19 | 6 | c.637C>T | p.R213X |
| 20 | 7 | c.743C>T | p.R248Q |
| 21 | 6 | c.549A>T | p.R282W |
| 22 | 5 | c.455dupCGC | p.G154fs |
| 23 | 5 | c.379C>T | p.R248Q |
| 24 | 5 | c.765G>C | p.R175H |
| 25 | 6 | c.103dupC | p.R202fs |
| 26 | 8 | c.503G>T | p.R249S |
| 27 | 5 | c.476C>T | p.R273H |
| 28 | 6 | c.583dupA | p.I195fs |
| 29 | 6 | c.586C>T | p.R282W |
| 30 | 5 | c.148G>C | p.R175H |
| 31 | 5 | c.337C>T | p.R248Q |
| 32 | 7 | c.709A>G | p.Y234C |
| 33 | 5 | c.487A>T | p.R175H |
| 34 | 5 | c.517G>T | p.V173L |
| 36 | 8 | c.839dupG | p.R273H |
| 37 | 5 | c.360_406del34 | p.L130fs |
| 39 | 5 | c.226_229delG | p.V143fs |
| 40 | 5 | c.767C>G | p.R282W |
| 41 | 6 | c.592G>T | p.R249S |
| 42 | 5 | c.451C>T | p.P151S |
| 43 | 7 | c.907T>A | p.R175H |
| 44 | 5 | c.493dupC | p.Q165fs |
| 45 | 6 | c.567_610dup44 | p.E204fs |
| 46 | 5 | c.469G>T | p.V157F |
| 47 | 5 | c.366A>T | p.R175H |
| 48 | 8 | c.818G>A | p.R273H |
| 49 | 5 | c.233G>C | p.R213W |
| 50 | 8 | c.797G>A | p.G249E |
| 52 | 7 | c.733G>A | p.G245S |
| 53 | 7 | c.680dupC | p.S227fs |
| 54 | 5 | c.234C>G | p.R175H |
| 55 | 6 | c.737C>T | p.G266E |
| 56 | 6 | c.537C>T | p.R249S |
| 57 | 5 | c.212C>G | p.R248Q |
| 58 | 6 | c.346_378delGA | p.Q192del |
| 59 | 7 | c.1037A>T | p.E192C |
| 60 | 8 | c.211C>G | p.R175H |
| 61 | 5 | c.537C>T | p.R356W |
| 63 | 6 | c.637G>T | p.R248Q |
| 64 | 5 | c.119A>G | p.R175H |
| 65 | 8 | c.785delG | p.G262fs |
| 66 | 5 | c.490G>T | p.R248Q |
| 67 | 8 | c.101delC | p.R213Q |
| 68 | 5 | c.568G>C | p.R175H |
| 69 | 6 | c.243G>T | p.R356W |
| 71 | 7 | c.769C>G | p.L257V |
| 72 | 7 | c.713G>A | p.C238Y |
| 73 | 6 | c.1106G>T | p.R175H |
| 75 | 5 | c.451C>T | p.P151S |
| 76 | 5 | c.428T>G | p.V143G |
| 77 | 8 | c.853_857delGAGG | p.E285fs |
| 79 | 5 | c.547G>C | p.R249S |
| 80 | 6 | c.208A>T | p.R238W |
| 81 | 5 | c.524G>T | p.R175H |
| 82 | 8 | c.670G>C | p.W238T |
| 83 | 5 | c.527G>T | p.C176F |
| 84 | 5 | c.536A>G | p.H179R |
| 85 | 5 | c.404G>T | p.C135F |
| 86 | 7 | c.743C>G | p.R248Q |
| 87 | 6 | c.574G>C | p.R175H |
| 88 | 5 | c.464C>A | p.T155N |
| 89 | 5 | c.512A>G | p.E171G |
| 90 | 5 | c.337A>T | p.G245S |
| 91 | 7 | c.748G>C | p.R249S |
| 92 | 6 | c.570C>T | p.R248Q |
| 93 | 5 | c.524G>A | p.R175H |
| 94 | 6 | c.599delA | p.N200fs |
| 95 | 7 | c.790delC | p.L287K |
| 96 | 5 | c.535C>T | p.H179Y |
| 97 | 7 | c.743C>G | p.R248Q |
| 99 | 6 | c.643A>C | p.S215R |
| 100 | 7 | c.730G>T | p.G244C |