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. 2020 Oct 26;7(4):e138. doi: 10.14440/jbm.2020.319

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Figure 8. — Time course of carrageenan-induced oedema in the in vivo rat paw test following administration of PNIPAM nanogels. Results, expressed as % swelling determined at different times after injection of carrageenan in the left hind foot pad. Key: Green: naproxen solution control, Blue: blank nanogel control, Red: NNCA (naproxen nanogel with citric acid), Black: NNCA + SC (mean ± SD, n = 3). Note: lowest swelling when dosed with NNCA + SC (naproxen nanogel + citric acid, activated by sodium carbonate).