Table 2.

Extracellular matrix markers in advanced compared with non-advanced autoimmune liver disease.

	PSC					PBC					AIH
	Test panel					Test panel					Test panel
	Non-advanced		Advanced		p value	Non-advanced		Advanced		p value	Non-advanced		Advanced		p value
N	35		41			44		27			36		18
Pro-C3/C3M	1.4	(0.6–5.0)	3.0	(0.7–6.4)	<0.001	1.1	(0.4–4.3)	1.7	(0.5–6.5)	<0.001	1.2	(0.2–2.2)	1.3	(0.6–7.9)	0.25
Pro-C3	13.3	(6.8–84.7)	42.2	(11.7–104.0)	<0.001	17.6	(8.0–66.9)	40.3	(9.4–107.6)	<0.001	12.1	(7.3–35.5)	19.8	(10.6–82.1)	0.001
Pro-C5	808.0	(359.5–2,990.2)	795.9	(56.1–3,035.2)	0.81	1,219.6	(211.7–3,464.4)	1,497.9	(699.8–3,496.9)	0.07	743.2	(339.6–3,309.6)	1,119.4	(498.2–1,889.5)	0.05
C3M	10.7	(5.6–31.4)	12.8	(7.2–48.9)	0.05	16.1	(8.0–80.2)	19.6	(9.5–44.8)	0.03	12.3	(6.1–32.9)	15.6	(9.5–33.2)	0.02
C4M	27.2	(15.0–73.4)	29.4	(14.6–65.7)	0.70	38.7	(20.1–91.5)	50.3	(25.0–96.9)	0.04	27.1	(14.6–73.2)	35.5	(19.3–70.9)	0.02
BGM	15.8	(4.6–64.1)	15.8	(4.6–48.2)	0.43	19.6	(4.6–47.2)	25.1	(10.0–96.73)	0.05	13.2	(4.6–39.9)	15.4	(4.6–26.9)	0.67
VICM	6.8	(0.7–36.2)	7.2	(0.7–35.3)	0.53	9.2	(0.7–57.6)	5.1	(0.7–59.2)	0.01	11.3	(0.7–54.4)	5.1	(0.7–36.3)	0.03

Advanced disease is defined by liver stiffness measurement using published cut-off values by transient elastography for PSC (F3; 9.6 kPa), PBC (F3; 10.7 kPa) and AIH (F3; 10.4 kPa). Median (range) values are given. The Mann-Whitney U test is used for comparisons. AIH, autoimmune hepatitis; BGM, biglycan marker; ECM, extracellular matrix; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; VICM, citrullinated vimentin.