Fig. 2.

Bladder/Prostatic biopsy.

The bladder biopsy (A) shows nests of high-grade urothelial carcinoma invading the lamina propria in the background of extensive necrosis and inflammation. The specimen from prostate biopsy (B) also shows high grade invasive urothelial carcinoma that is morphologically similar to the tumor in bladder biopsy. Immunohistochemical studies on the bladder biopsy (C) and the prostate biopsy (D) demonstrate that the tumor cells are positive for GATA-3 and negative for PSA, supporting urothelial origin.