Table 3. Multivariable-Adjusted Association of Alternative Healthy Eating Index 2010 With Erectile Dysfunction Among Men From the Health Professionals Follow-up Study Stratified by Age.
| Outcome | Quintile of Alternative Healthy Eating Index 2010a | P for trendb | ||||
|---|---|---|---|---|---|---|
| Q1 (less healthy) | Q2 | Q3 | Q4 | Q5 (healthier) | ||
| Age <60 y | ||||||
| Events/person-years, No. | 266/12 299 | 219/11 754 | 185/10 959 | 168/10 281 | 130/7951 | NA |
| Event rate, per 1000 person-years | 21.6 | 18.4 | 16.9 | 16.3 | 16.4 | NA |
| Index score, mean (SD) | 35 (4) | 44 (2) | 49 (2) | 55 (2) | 63 (4) | NA |
| Age-adjusted model, HR (95% CI) | 1 [Reference] | 0.83 (0.69-0.99) | 0.76 (0.63-0.92) | 0.71 (0.58-0.86) | 0.68 (0.55-0.84) | <.001 |
| Multivariable model, HR (95% CI)c | 1 [Reference] | 0.87 (0.72-1.04) | 0.80 (0.66-0.97) | 0.78 (0.64-0.95) | 0.78 (0.63-0.97) | .007 |
| Age 60 to <70 y | ||||||
| Events/person-years, No. | 731/19 212 | 758/21 748 | 807/21 925 | 775/22 552 | 632/21 612 | NA |
| Event rate, per 1000 person-years | 38.0 | 34.9 | 36.8 | 34.4 | 29.2 | NA |
| Index score, mean (SD) | 36 (4) | 44 (2) | 50 (2) | 55 (2) | 64 (4) | NA |
| Age-adjusted model, HR (95% CI) | 1 [Reference] | 0.91 (0.82-1.00) | 0.94 (0.85-1.03) | 0.86 (0.77-0.95) | 0.71 (0.64-0.79) | <.001 |
| Multivariable model, HR (95% CI)c | 1 [Reference] | 0.92 (0.83-1.01) | 0.96 (0.87-1.06) | 0.89 (0.80-0.98) | 0.78 (0.69-0.87) | <.001 |
| Age ≥70 y | ||||||
| Events/person-years, No. | 635/9626 | 875/13 236 | 950/13 841 | 1165/16 500 | 1168/19 026 | NA |
| Event rate, per 1000 person-years | 66.0 | 66.1 | 68.6 | 70.6 | 61.4 | NA |
| Index score, mean (SD) | 36 (4) | 44 (2) | 50 (2) | 55 (2) | 64 (5) | NA |
| Age-adjusted model, HR (95% CI) | 1 [Reference] | 0.98 (0.89-1.09) | 1.02 (0.92-1.12) | 1.03 (0.94-1.14) | 0.89 (0.81-0.98) | .02 |
| Multivariable model, HR (95% CI)c | 1 [Reference] | 0.99 (0.89-1.09) | 1.00 (0.91-1.11) | 1.03 (0.93-1.13) | 0.89 (0.81-0.99) | .03 |
Abbreviations: HR, hazard ratio; NA, not applicable; Q, quintile.
a
Higher dietary index score indicates greater adherence to the Healthy Eating Pyramid guidelines from the Department of Nutrition, Harvard T.H. Chan School of Public Health (total score range, 0 to 110). Exposures were defined as Q.
b
P value for trend calculated by modeling the median of each quintile.
c
Adjusted for age, race, body mass index, smoking, physical activity, hyperlipidemia, hypertension, depression, antidepressant or antipsychotic medication use, benzodiazepine use, α-blocker or 5α-reductase inhibitor use, incident cardiovascular disease or diabetes during follow-up, caloric intake, and marital status.