Table 2. Slopes of Linear Mixed Models of Blood Pressure Over Time by West African Ancestry Tertilesa.
| Period | Tertile 1 slope (95% CI) | Tertile 2 slope (95% CI) | Tertile 3 slope (95% CI) | Overall P valueb |
|---|---|---|---|---|
| Standard treatment arm | ||||
| SBP | ||||
| ≤6 mo | 6.92 (2.77 to 11.07) | 4.47 (0.09 to 8.85) | 2.11 (−2.65 to 6.86) | .33 |
| >6 mo | 0.00 (−0.41 to 0.42) | 0.22 (−0.20 to 0.63) | 0.26 (−0.22 to 0.74) | .68 |
| DBP | ||||
| ≤6 mo | 3.76 (0.73 to 6.80) | 3.69 (0.68 to 6.70) | 0.38 (−2.81 to 3.58) | .24 |
| >6 mo | −0.55 (−0.86 to −0.24) | −0.50 (−0.80 to −0.19) | −0.56 (−0.89 to −0.22) | .94 |
| Intensive treatment arm | ||||
| SBP | ||||
| ≤6 mo | −12.26 (−16.67 to −7.84) | −11.27 (−16.23 to −6.31) | −14.38 (−19.48 to −9.27) | .67 |
| >6 mo | −0.11 (−0.54 to 0.32) | −0.62 (−1.10 to −0.14) | −0.49 (−0.97 to −0.01) | .19 |
| DBP | ||||
| ≤6 mo | −7.98 (−10.99 to −4.97) | −6.03 (−9.32 to −2.75) | −8.17 (−11.37 to −4.97) | .60 |
| >6 mo | −0.47 (−0.77 to −0.17) | −1.05 (−1.38 to −0.72) | −0.34 (−0.66 to −0.02) | .003 |
Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure.
a
Models were adjusted for age, sex, education level, estimated glomerular filtration rate, history of cardiovascular disease, trial site, and APOL1 risk count.
b
Overall P value from analysis of variance using the Wald test for comparison of slopes across the 3 groups.