Table 3. Slopes of Linear Mixed Models of Kidney Function Parameters Over Time by West African Ancestry Tertilesa.
| Period | Tertile 1 slope (95% CI) | Tertile 2 slope (95% CI) | Tertile 3 slope (95% CI) | Overall P valueb |
|---|---|---|---|---|
| Standard treatment arm | ||||
| Estimated glomerular filtration rate | ||||
| ≤6 mo | 3.01 (−2.82 to 8.84) | 3.84 (−2.47 to 10.15) | 4.15 (−2.10 to 10.40) | .96 |
| >6 mo | −0.32 (−1.36 to 0.72) | −0.27 (−1.36 to 0.81) | 0.04 (−1.47 to 1.54) | .83 |
| Blood urea nitrogen | ||||
| ≤6 mo | 1.21 (−0.41 to 2.84) | 0.23 (−1.57 to 2.03) | 0.77 (−1.12 to 2.66) | .72 |
| >6 mo | −0.04 (−0.35 to 0.27) | −0.17 (−0.50 to 0.16) | 0.19 (−0.20 to 0.58) | .34 |
| Urine albumin-creatinine ratio | ||||
| ≤6 mo | 0.04 (−0.27 to 0.35) | 0.08 (−0.29 to 0.45) | −0.21 (−0.59 to 0.18) | .93 |
| >6 mo | 0.05 (−0.03 to 0.12) | 0.08 (0.01 to 0.16) | 0.01 (−0.08 to 0.10) | .66 |
| Intensive treatment arm | ||||
| Estimated glomerular filtration rate | ||||
| ≤6 mo | −4.03 (−10.22 to 2.16) | −4.55 (−10.81 to 1.71) | −4.96 (−11.56 to 1.64) | .98 |
| >6 mo | −0.59 (−1.59 to 0.42) | −1.06 (−2.14 to 0.02) | −0.87 (−0.20 to 0.25) | .83 |
| Blood urea nitrogen | ||||
| ≤6 mo | 4.11 (2.09 to 6.12) | 4.72 (2.77 to 6.67) | 5.28 (2.87 to 7.70) | .75 |
| >6 mo | −0.18 (−0.51 to 0.15) | −0.04 (−0.43 to 0.35) | 0.05 (−0.39 to 0.49) | .72 |
| Urine albumin-creatinine ratio | ||||
| ≤6 mo | −0.29 (−0.62 to 0.03) | −0.23 (−0.62 to 0.15) | −0.57 (−0.92 to −0.22) | .51 |
| >6 mo | 0.08 (0.01 to 0.15) | 0.01 (−0.07 to 0.08) | 0.03 (−0.05 to 0.11) | .86 |
a
Models were adjusted for age, sex, education level, estimated glomerular filtration rate, history of cardiovascular disease, trial site, and APOL1 risk count.
b
Overall P value from analysis of variance using the Wald test for comparison of slopes across the 3 groups.