Table 3.

Risk of CRC associated with a 1-SD increase in the circulating sRAGE level

	OR (95% CI)	P
Model 1	3.331 (2.075–5.347)	<0.001
Model 2	3.603 (2.089–6.217)	<0.001
Model 3	3.609 (2.081–6.257)	<0.001
Model 4	2.289 (1.037–5.051)	0.040

OR odds ratio, CI confidence interval. We assigned the value of 0 to participants without CRC and assigned the value of 1 to those with CRC. Model 1 was adjusted for age, sex, BMI and smoking status. Model 2 was further adjusted for triglyceride, total cholesterol, LDL-c, and HDL-c levels based on model 1. Model 3 was further adjusted for the HOMA-IR score based on model 2. Model 4 was further adjusted for IL-6 levels based on model 3.