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. 2020 Nov 13;18:167. doi: 10.1186/s12915-020-00894-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Population-stratified retention of ancestral sequences. a Top 10 F_ST signals in each continental group. Each row represents the non-reference insertion variants and the nearest genes within the 250-kbp range are listed with distances mentioned in parentheses. Each cell is colored according to the F_ST value. b Global distribution of I_709. c An unrooted maximum-likelihood tree based on the alignment of 30-kbp flanking sequences of I_709 from 16 human assemblies. Assemblies with ancestral sequences are indicated by blue boxes and those with deletion alleles by red circles. d Expression of GOLIM4 according to the genotypes of the I_709 variant