Table 3.
Multivariate analysis of prognostic factors
| Characteristics | P value | HR | 95% CI for HR |
|---|---|---|---|
| Age at diagnosis | |||
| 40–44 years | Reference | ||
| 45–49 years | 0.542 | 0.932 | 0.741–1.170 |
| 50–54 years | 0.878 | 1.017 | 0.821–1.260 |
| 55–59 years | 0.024 | 1.270 | 1.032–1.562 |
| Race | |||
| White | Reference | ||
| Black | 0.001 | 1.317 | 1.127–1.540 |
| Other a | 0.128 | 1.192 | 0.951–1.495 |
| Marital status | |||
| Single | Reference | ||
| Married | 0.008 | 0.819 | 0.707–0.949 |
| Other b | 0.130 | 0.871 | 0.728–1.042 |
| Insurance (yes vs no) | < 0.001 | 0.587 | 0.459–0.751 |
| Histology | |||
| Ductal | Reference | ||
| Lobular | 0.744 | 1.041 | 0.820–1.321 |
| Others | 0.356 | 1.105 | 0.894–1.365 |
| Laterality | |||
| Right | Reference | ||
| Left | 0.506 | 1.043 | 0.921–1.182 |
| Bilateral, single primary | 0.177 | 2.21 | 0.894–1.365 |
| Grade | |||
| I | Reference | ||
| II | 0.309 | 1.147 | 0.881–1.492 |
| III or IV | < 0.001 | 1.960 | 1.491–2.577 |
| Tumour subtype | |||
| HR+/HER2- | Reference | ||
| HR+/HER2+ | 0.002 | 0.631 | 0.474–0.839 |
| HR−/HER2- | < 0.001 | 2.808 | 2.169–3.634 |
| HR−/HER2+ | 0.258 | 0.716 | 0.401–1.277 |
| Site of metastases | |||
| Lung (yes vs no) | 0.020 | 1.378 | 1.188–1.598 |
| Liver (yes vs no) | < 0.001 | 2.085 | 1.795–2.422 |
| Brain (yes vs no) | < 0.001 | 1.903 | 1.542–2.248 |
| Surgery (yes vs no) | < 0.001 | 0.504 | 0.431–0.590 |
| HR+/HER2- * multi-metastases | Reference | ||
| HR+/HER2+ * multi-metastases | 0.045 | 0.694 | 0.485–0.992 |
| HR−/HER2- * multi-metastases | 0.717 | 0.941 | 0.675–1.310 |
| HR−/HER2+ * multi-metastases | 0.564 | 0.828 | 0.437–1.572 |
| Next step | |||
| White*HR+/HER2- | Reference | ||
| Black*HR+/HER2+ | 0.366 | 0.821 | 0.536–1.258 |
| Other a*HR+/HER2+ | 0.652 | 0.862 | 0.453–1.641 |
| Black*HR−/HER2- | 0.323 | 0.817 | 0.546–1.220 |
| Other a*HR−/HER2- | 0.299 | 1.508 | 0.695–3.271 |
| Black*HR−/HER2+ | 0.696 | 0.881 | 0.466–1.664 |
| Other a*HR−/HER2+ | 0.368 | 0.701 | 0.323–1.521 |
Other a (American Indian/AK Native, Asian/Pacific Islander)
Other b (divorced/widowed/separated).