Table 2.
S gene mutations from the current study
| HBV S gene region | Mutation | Accession number | HBsAg Sero status |
|---|---|---|---|
| MHR (aa 99–169) | |||
| ‘a’ determinant region (aa 124–147) | T143M | MT185642 | Negative |
| MT185646 | Negative | ||
| M133T | MT185649 | ||
| D144G | MT185649 | Positive | |
| Outside ‘a’ determinant region (aa 99–123 and 148–169) | T114P | MT185645 | Negative |
| MT185643 | Negative | ||
| MT185647 | Negative | ||
| A159V | MT185642 | Negative | |
| MT185646 | Negative | ||
| F158L | MT185643 | Negative | |
| Downstream of the MHR (aa 170–207) | A194V | MT185650 | Negative |
| MT185649 | Positive | ||
| MT185648 | Negative | ||
| Y206E | MT185642 | Negative | |
| MT185646 | Negative | ||
| S207K | MT185650 | Negative | |
| MT185649 | Positive |
These mutations were identified using two online tools Geno2Pheno HBV database (HBVdb) (https://hbv.geno2pheno.org/) and HBVseq program from HIV Stanford database (https://hivdb.stanford.edu/HBV/HBVseq/development/HBVseq.html). The mutations are listed for each of the sample where they occurred