Table 1.
Demographics of the Cohort Stratified by Bloodstream Infection (N = 11,183 cultures)
| Negative | Positive | P* | |
|---|---|---|---|
| n | 10,559 | 624 | |
| Male Sex | 5841 (55.3) | 330 (52.9) | 0.252 |
| Mean Age (SD) | 7.10 (4.82) | 7.47 (5.11) | 0.062 |
| Down Syndrome | 263 (2.5) | 26 (4.2) | 0.015 |
| ICCC Category | < 0.001 | ||
| I. Leukemias, Myeloproliferative Diseases and Myelodysplastic Diseases | 5070 (48.0) | 403 (64.6) | |
| II. Lymphomas and Reticuloendothelial Neoplasms | 1325 (12.5) | 56 (9.0) | |
| III. Central Nervous System Tumors | 1223 (11.6) | 52 (8.3) | |
| IV. Neuroblastoma | 899 (8.5) | 48 (7.7) | |
| V. Retinoblastoma | 127 (1.2) | 3 (0.5) | |
| VI. Renal Tumors | 248 (2.3) | 2 (0.3) | |
| VII. Hepatic Tumors | 168 (1.6) | 4 (0.6) | |
| VIII. Malignant Bone Tumors | 528 (5.0) | 15 (2.4) | |
| IX. Soft-tissue and Other Extraosseous Sarcomas | 573 (5.4) | 20 (3.2) | |
| X. Germ Cell Tumors | 146 (1.4) | 3 (0.5) | |
| XI. Other Malignant Epithelial Neoplasms | 103 (1.0) | 6 (1.0) | |
| XII. Other and unspecified malignant neoplasms | 19 (0.2) | 1 (0.2) | |
| Not cancer undergoing HSCT | 130 (1.2) | 11 (1.8) | |
| Ordinal Cancer | 0.904 | ||
| 1 | 10,446 (98.9) | 617 (98.9) | |
| 2 | 105 (1.0) | 7 (1.1) | |
| 3 or 4 | 8 (0.1) | 0 (0.0) | |
| Relapse | 1132 (10.7) | 134 (21.5) | < 0.001 |
| Prior Hematopoietic Stem Cell Transplant | |||
| Allogeneic | 739 (7.0) | 94 (15.1) | < 0.001 |
| Autologous | 914 (8.7) | 61 (9.8) | 0.373 |
Abbreviations: SD Standard deviation, ICCC International Classification of Childhood Cancer, HSCT Hematopoietic stem cell transplantation
*P values calculated using Student’s t-test for continuous variables and chi square test for categorical variables