Table 2.
Factors associated with disease activity over time among incident cases of polyarticular JIA
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| β | [95% CI] | p-value | β | [95% CI] | p-value | |
| Age at index visit | 0.17 | [0.02, 0.32] | 0.02 | 0.11 | [− 0.04, 0.25] | 0.14 |
| Male sex | 0.27 | [−1.71, 2.25] | 0.79 | – | ||
| Race | ||||||
| White | – | – | ||||
| Black | 2.83 | [1.14, 4.52] | 0.00 | 2.46 | [0.80, 4.11] | < 0.01 |
| Asian/Other | −0.70 | [−2.51, 1.12] | 0.45 | −0.78 | [−2.46, 0.9] | 0.36 |
| Hispanic ethnicity | − 2.81 | [−8.06, 2.44] | 0.29 | – | ||
| Public insurance | 1.06 | [−0.45, 2.58] | 0.17 | – | ||
| RF positivity | 1.16 | [−0.43, 2.75] | 0.15 | −0.71 | [−2.32, 0.9] | 0.39 |
| Baseline cJADAS-10 | 0.47 | [0.34, 0.61] | 0.00 | 0.48 | [0.36, 0.61] | < 0.01 |
| Non-biologic DMARD usea | −1.72 | [−2.86, −0.58] | 0.00 | −2.66 | [−3.78, − 1.55] | < 0.01 |
| Biologic usea | − 1.46 | [− 2.80, − 0.12] | 0.03 | −1.88 | [− 3.14, − 0.61] | < 0.01 |
| Time (months) | − 1.24 | [− 1.41, − 1.06] | 0.00 | −1.07 | [− 1.27, − 0.88] | < 0.01 |
| Time-squared | 0.03 | [0.02, 0.04] | 0.00 | 0.03 | [0.02, 0.03] | < 0.01 |
Marginal effect of covariates on repeated measures of cJADAS over time, estimated from linear mixed-effects models for incident cases of polyarticular JIA
aTime-varying covariate
RF rheumatoid factor; cJADAS-10 clinical Juvenile Arthritis Disease Activity Score; DMARD disease-modifying anti-rheumatic drug