Table 3.
Factors associated with disease activity over time among prevalent cases of polyarticular JIA
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| β | [95% CI] | p-value | β | [95% CI] | p-value | |
| Age at index visit | 0.04 | [− 0.09, 0.18] | 0.52 | – | ||
| Male sex | 0.23 | [−1.45, 1.91] | 0.79 | – | ||
| Race | ||||||
| White | – | – | ||||
| Black | 3.16 | [1.00, 5.32] | < 0.01 | 1.16 | [−0.12, 2.44] | 0.08 |
| Asian/Other | −0.39 | [−2.24, 1.46] | 0.68 | −0.40 | [−1.45, 0.65] | 0.46 |
| Hispanic ethnicity | −0.99 | [−3.54, 1.55] | 0.44 | |||
| Public insurance | 1.00 | [−0.27, 2.26] | 0.12 | 0.54 | [−0.17, 1.25] | 0.14 |
| RF positivity | 0.36 | [−1.57, 2.29] | 0.72 | |||
| Baseline cJADAS-10 | 0.56 | [0.49, 0.62] | < 0.01 | 0.54 | [0.47, 0.61] | < 0.01 |
| Non-biologic DMARD usea | −0.51 | [−1.34, 0.32] | 0.23 | |||
| Biologic usea | −1.13 | [−2.07, −0.18] | 0.02 | −0.43 | [− 1.09, 0.23] | 0.20 |
| Time (months) | −0.15 | [−0.24, − 0.07] | < 0.01 | −0.13 | [− 0.21, − 0.04] | < 0.01 |
| Time-squared | 0.004 | [0.001, 0.01] | < 0.01 | 0.003 | [0.001, 0.01] | 0.01 |
Marginal effect of covariates on repeated measures of cJADAS over time, estimated from linear mixed-effects models for prevalent cases of polyarticular JIA
aTime-varying covariate
RF rheumatoid factor; cJADAS-10 clinical Juvenile Arthritis Disease Activity Score; DMARD disease-modifying anti-rheumatic drug