Table X.
Logistic regression models of severe disease
| Predictors | Bivariate |
Multivariable |
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|---|---|---|---|---|---|---|
| Model 1 (N = 106) |
Model 2 (N = 127) |
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| OR (95% CI) | P value | aOR (95% CI) | P value | aOR (95% CI) | P value | |
| Respiratory illness: 56 events, N = 141 | ||||||
| Age (per 1-year decrease) | 1.02 (0.98-1.08) | .29 | 1.09 (1.01-1.18) | .02 | 1.09 (1.02-1.16) | .01 |
| BMI∗ (per unit increase in kg/m2) | 1.01 (0.98-1.04) | .49 | ||||
| Obesity∗ (reference = no obesity) | 1.78 (0.85-3.73) | .12 | 3.66 (1.14-11.78) | .03 | 3.39 (1.26-9.10) | .02 |
| Days of illness before admission | 1.02 (0.94-1.11) | .64 | ||||
| Admission WBC (per unit increase in 109/L) | 1.07 (1.01-1.14) | .03 | 1.11 (1.01-1.21) | .03 | 1.11 (1.03-1.20) | .007 |
| Admission absolute lymphocyte count (per unit decrease in U/L) | 0.92 (0.79-1.08) | .31 | ||||
| Admission CRP level (per unit increase in mg/dL) | 1.02 (1.00-1.04) | .09 | ||||
| Hispanic (reference = non-Hispanic white/other) | 1.29 (0.49-3.37) | .61 | 0.88 (0.26-2.98) | .84 | ||
| Non-Hispanic black (reference = non-Hispanic white/other) | 1.77 (0.50-6.20) | .37 | 1.65 (0.31-8.87) | .56 | ||
| Medicare/Medicaid (reference = private/other) | 0.95 (0.45-2.04) | .9 | ||||
| Oxygen saturation <90% (reference = no) | 3.55 (1.13-11.20) | .03 | 4.25 (1.10-16.49) | .04 | 4.01 (1.14-14.15) | .03 |
| Male (reference = female) | 0.91 (0.45-1.85) | .79 | ||||
| Medical complexity∗ (reference = no) | 1.99 (0.94-4.21) | .07 | 1.51 (0.51-4.42) | .45 | ||
| Bilateral infiltrates on radiograph (reference = no) | 3.14 (1.51-6.53) | .002 | 3.88 (1.36-11.08) | .01 | 3.69 (1.46-9.32) | .006 |
| Low SES∗ (reference ≥–1) |
0.86 (0.31-2.38) |
.77 |
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| Predictor |
Bivariate |
Multivariable |
||||
| Model 1 (N = 60) |
Model 2 (N = 66) |
|||||
| OR (95% CI) |
P value |
aOR (95% CI) |
P value |
aOR (95% CI) |
P value |
|
| MIS-C: 38 events, N = 68 | ||||||
| Age (per 1-year decrease) | 0.83 (0.74-0.93) | .002 | 1.00 (0.84-1.19) | .98 | ||
| BMI∗ (per unit increase in kg/m2) | 1.02 (0.92-1.14) | .69 | ||||
| Obesity∗ (reference = no obesity) | 1.16 (0.35-3.91) | .81 | ||||
| Days of illness before admission | 0.98 (0.77-1.25) | .87 | ||||
| WBC (per unit increase in 109/L) | 0.95 (0.88-1.04) | .29 | ||||
| Admission absolute lymphocyte count (per unit decrease in U/L) | 5.88 (2.13-16.67) | <.001 | 12.50 (1.85-100.0) | .009 | 8.33 (2.32-33.33) | .001 |
| Admission CRP level (per unit increase in mg/dL) | 1.04 (1.00-1.07) | .03 | 1.05 (0.98-1.12) | .14 | 1.06 (1.01-1.12) | .02 |
| Hispanic (reference = Non-Hispanic white/other) | 1.09 (0.26-4.55) | .9 | 2.54 (0.23-28.23) | .45 | ||
| Non-Hispanic black (reference = non-Hispanic white/other) | 4.05 (0.87-18.93) | .07 | 3.09 (0.22, 42.80) | .4 | ||
| Medicare/Medicaid (reference = private/other) | 0.39 (0.14-1.12) | .08 | 0.21 (0.04-1.15) | .07 | ||
| Male (reference = female) | 1.66 (0.60-4.60) | .33 | ||||
| Medical complexity∗ (reference = no) | 0.51 (0.08-3.37) | .49 | ||||
| Bilateral infiltrates on radiograph (reference = no) | 6.59 (0.73-59.81) | .09 | ||||
| Low SES∗ (reference ≥–1) | 0.78 (0.23-2.62) | .69 | ||||
BMI, body mass index.
P values for OR and aOR estimated using logistic regression. All estimates are adjusted for site with fixed effects. Excluded 2 Respiratory cases (one who was chronically ventilator-dependent and discharged on hospital day 1, and one who died on the day of admission) and 1 MIS-C case (transferred on the day of admission). Model 1 includes variables with P < .25 in bivariate analysis, age and race. Model 2 includes only variables with P < .05 using stepwise backward selection strategy. CRP level excluded in multivariable Respiratory models because 28% missing and data not missing at random. Bilateral infiltrates on radiograph not included in multivariable MIS-C due to limited number of MIS-C patients with this condition (N = 7).
See definitions in Table II.