Table XI.
Sensitivity analysis: logistic regression models for severe outcome using multiple imputation for missing data
| Case description | Multivariable model 1 |
Multivariable model 2 |
||
|---|---|---|---|---|
| aOR (95% CI) | P value | aOR (95% CI) | P value | |
| Respiratory illness: 56 events, N = 141 | ||||
| Age (per 1-year decrease) | 1.09 (1.02-1.16) | .01 | 1.09 (1.02-1.15) | .01 |
| Obesity∗ (reference = no) | 3.48 (1.22- 9.96) | .02 | 2.84 (1.09-7.39) | .03 |
| Admission WBC count (per unit increase in 109/L) | 1.11 (1.02-1.21) | .01 | 1.10 (1.02-1.19) | .02 |
| Hispanic (reference = non-Hispanic white/other) | 0.93 (0.30-2.90) | .90 | ||
| Non-Hispanic black (reference = non-Hispanic white/other) | 1.64 (0.34-7.90) | .54 | ||
| Oxygen saturation <90% (reference = no) | 3.56 (0.98-12.95) | .05 | 4.08 (1.17-14.27) | .03 |
| Medical complexity∗ (reference = no) | 2.34 (0.94-5.81) | .07 | ||
| Bilateral infiltrates on radiograph (reference = no) |
4.05 (1.59-10.30) |
.003 |
3.88 (1.59-9.48) |
.003 |
| Multivariable model 1 |
||||
| aOR (95% CI) |
P value |
|||
| MIS-C: 38 events, N = 68 | ||||
| Age (per 1-year decrease) | 0.98 (0.84, 1.16) | .85 | ||
| Admission absolute lymphocyte count (per unit decrease in U/L) | 6.25 (1.41, 25.0) | .02 | ||
| Admission CRP level (per unit increase in mg/dL) | 1.03 (0.97, 1.09) | .33 | ||
| Hispanic (reference = non-Hispanic white/other) | 1.20 (0.14, 10.09) | .87 | ||
| Non-Hispanic black (reference = non-Hispanic white/other) | 2.86 (0.24, 33.71) | .40 | ||
| Medicaid/Medicare (reference = private/other) | 0.40 (0.09, 1.68) | .21 | ||
P values for aOR estimated using logistic regression. All estimates are adjusted for site with fixed effects.
For respiratory illness, excluded 2 respiratory cases (one who was chronically ventilator-dependent and discharged on hospital day 1, and one who died on the day of admission). Multiple imputation model included outcome, all predictor variables listed in Table X and hospital site. Results based on 40 imputed data sets.
For MIS-C, excluded 1 MIS-C case (transferred on the day of admission). Multiple imputation model included outcome, all predictor variables listed in Table X and hospital site. Results based on 40 imputed data sets. Model 1 includes variables with P < .25 in bivariate analysis, age and race. Model 2 had nearly complete data (2 missing values) so multiple imputation not performed.
See definitions in Table II.