Table XII.
Patient characteristics by disease severity status
| Clinical measures | Respiratory |
MIS-C |
Other |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-severe |
Severe |
P value∗ | Non-severe |
Severe |
P value∗ | Non-severe |
Severe |
P value∗ | |
| N = 85 | N = 56 | N = 30 | N = 38 | N = 65 | N = 4 | ||||
| Age, y | 17 (2-20) | 13 (3-16) | .12 | 3 (1-7) | 10 (6-13) | <.001 | 6 (0-16) | 11 (4-17) | .32 |
| Male | 53/85 (62%) | 33/56 (59%) | .73 | 17/30 (57%) | 25/38 (66%) | .46 | 38/65 (58%) | 3/4 (75%) | .64 |
| Race/ethnicity | |||||||||
| Hispanic | 44/70 (63%) | 26/48 (54%) | .37 | 15/28 (54%) | 12/36 (33%) | .09 | 26/56 (46%) | 2/4 (50%) | .25 |
| Non-Hispanic black | 9/70 (13%) | 11/48 (23%) | 6/28 (21%) | 17/36 (47%) | 11/56 (20%) | 2/4 (50%) | |||
| Non-Hispanic white/other | 17/70 (24%) | 11/48 (23%) | 7/28 (25%) | 7/36 (19%) | 19/56 (34%) | 0/4 (0%) | |||
| Insurance | |||||||||
| Medicaid/Medicare | 57/85 (67%) | 38/56 (68%) | >.99 | 21/30 (70%) | 17/38 (45%) | .05 | 50/65 (77%) | 3/4 (75%) | >.99 |
| SES by ZIP code | |||||||||
| Low SES† | 32/85 (38%) | 15/56 (27%) | .20 | 11/30 (37%) | 10/38 (26%) | .43 | 16/65 (25%) | 3/4 (75%) | .061 |
| Coexisting conditions | |||||||||
| Obesity† | 34/81 (42%) | 27/51 (53%) | .28 | 6/25 (24%) | 12/38 (32%) | .58 | 5/49 (10%) | 0/3 (0%) | >.99 |
| Medical complexity† | 22/85 (26%) | 22/56 (39%) | .099 | 3/30 (10%) | 2/38 (5%) | .65 | 8/65 (12%) | 1/4 (25%) | .44 |
| Vital signs on admission | |||||||||
| O2 saturation of <90% | 6/85 (7%) | 10/56 (18%) | .06 | 0/30 (0%) | 0/38 (0%) | – | 0/65 (0%) | 0/4 (0%) | – |
| Tachypnea for age† | 19/85 (22%) | 28/56 (50%) | <.001 | 8/30 (27%) | 10/38 (26%) | >.99 | 1/65 (2%) | 0/4 (0%) | >.99 |
| Days of illness before admission | 3 (1-7) | 4 (2-7) | .33 | 5 (3-6) | 5 (4-6) | .95 | 1 (1-3) | 2 (1-4) | .65 |
| Laboratories and imaging | |||||||||
| Peak CRP >25, mg/dL | 4/57 (7%) | 14/45 (31%) | .003 | 10/29 (34%) | 24/37 (65%) | .03 | 3/35 (9%) | 0/1 (0%) | >.99 |
| Peak procalcitonin >0.5, ng/mL | 8/40 (20%) | 16/31 (52%) | .01 | 13/18 (72%) | 29/30 (97%) | .02 | 5/15 (33%) | 0/1 (0%) | >.99 |
| Peak ESR >50, mm/h | 7/17 (41%) | 15/23 (65%) | .20 | 16/23 (70%) | 18/26 (69%) | >.99 | 2/13 (15%) | 0/1 (0%) | >.99 |
| Peak ferritin >500, ng/mL | 21/43 (49%) | 23/43 (53%) | .83 | 10/25 (40%) | 29/37 (78%) | .003 | 4/21 (19%) | 0/1 (0%) | >.99 |
| Peak troponin >0.01, ng/mL | 5/43 (12%) | 11/30 (37%) | .02 | 6/22 (27%) | 27/35 (77%) | <.001 | 2/17 (12%) | 1/2 (50%) | .30 |
| Peak BNP >500, ng/L | 5/31 (16%) | 10/24 (42%) | .07 | 16/22 (73%) | 29/36 (81%) | .53 | 3/12 (25%) | 0/1 (0%) | >.99 |
| Nadir absolute lymphocyte count <1.0, × 109/L | 29/76 (38%) | 31/54 (57%) | .03 | 7/29 (24%) | 27/38 (71%) | <.001 | 10/56 (18%) | 0/3 (0%) | >.99 |
| Nadir platelets <100, × 109/L | 4/77 (5%) | 14/54 (26%) | .001 | 3/30 (10%) | 19/38 (50%) | <.001 | 3/59 (5%) | 0/3 (0%) | >.99 |
| Nadir sodium <130, mEq/L | 4/78 (5%) | 11/55 (20%) | .01 | 3/29 (10%) | 13/38 (34%) | .04 | 4/58 (7%) | 1/4 (25%) | .29 |
| Viral coinfection | 2/85 (2%) | 4/56 (7%) | .21 | 0/30 (0%) | 2/38 (5%) | .50 | 2/65 (3%) | 1/4 (25%) | .17 |
BNP, B-type natriuretic peptide; ESR, erythrocyte sedimentation rate.
Data are presented as median (IQR) for continuous measures, and n/total (%) for categorical measures.
∗
Continuous variables were compared using Wilcoxon rank-sum, categorical variables were compared using Fisher exact tests; Severity analysis excluded 1 MIS-C case (transferred on the day of admission) and 2 respiratory cases (one who was chronically ventilator-dependent and discharged on hospital day 1, and one who died on the day of admission).
†
See definitions in Table II.