Figure 2.

Architecture of the Extended E-RTC

(A) Domain organization of each component in the extended E-RTC. The color scheme for nsp7, nsp8, nsp12, and nsp13 is generally the same as that used in our previous work (Gao et al., 2020) with modifications. Nsp7, deep purple; nsp8-1, gray; nsp8-2, green cyan; nsp9, magenta; nsp12 NiRAN, yellow; nsp12 Interface, orange; nsp12 Fingers, blue; nsp12 Palm, red; nsp12 Thumb, green; nsp13 ZBD, light green; nsp13 S, light salmon; nsp13 1B, light magenta; nsp13 1A, sand; nsp13 2A, red pink.

(B) Cryo-EM densities (upper panels) and cartoon representations (lower panels) of the extended E-RTC shown in three perpendicular views.