Figure 3.

Interface between the Nsp9 and Nsp12 Protomers

(A–C) Two regions at the nsp9-nsp12 interface are highlighted by red (A) and blue frames and are enlarged in (B) and (C). The extended E-RTC is shown as a cartoon diagram with the color scheme the same as in Figure 1. Key residues at the nsp9-nsp12 interface are shown as colored sticks. The dashed lines indicated the bonds with the distance less than 3.5 Å.

(D and E) Sequence alignments of the key regions at the nsp9-nsp12 interface (D), GDP binding (E) (related to Figure 4). The key contact residues are highlighted by colored backgrounds with the same color as the domain or protein where they are located.