Fig. 3.

The effects of cinanserin on depression- and anxiety-like responses in the NARS and ARS mice by the EPM and FST. (A) ARS, at a period of 4 h, enhanced immobility time in the FST in comparison with the saline group. In ARS mice, i.c.v. microinjection of cinanserin (1, 2.5, and 5 μg/mouse) decreased immobility time in the FST compared to the control and respective control groups. (B) All doses of cinanserin increased OAT of ARS mice compared to the control and respective control groups. (C) Non-doses of cinanserin had no significant effect on OAE in comparison with the control group. (D) Cinanserin did not affect the locomotor activity at any used doses compared to the control group. Data are expressed as means ± SEM (n = 8 mice/group). **p < 0.01 and *p < 0.05 in comparison with the saline/saline group. ++p < 0.01 and +p < 0.05 compared to the saline/cinanserin group