Table 3.

Average backbone RMSD (in Å) of all complexes. The standard errors of the mean (SEM) are listed in the parentheses. The average and SEM values were determined using the block average method.

System	Reference	Lurasidone	Lurasidone exo	Lurasidone endo	Lurasidone sulfoxide	Fananserin
Mpro	2.08 (0.03)	1.54 (0.04)	1.59 (0.03)	2.11 (0.07)	2.28 (0.03)	2.50 (0.06)
PLpro	1.75 (0.07)	1.58 (0.03)	1.79 (0.3)	1.48 (0.02)	2.15 (0.04)	1.62 (0.02)
Spro	1.33 (0.02)	1.45 (0.02)	1.60 (0.03)	1.45 (0.02)	1.70 (0.02)	1.28 (0.02)
RdRp	2.37 (0.04)	2.31 (0.05)	1.99 (0.02)	2.55 (0.04)	2.11 (0.02)	1.86 (0.02)
Helicase	1.74 (0.03)	2.78 (0.12)	2.71 (0.06)	2.90 (0.07)	2.07 (0.06)	2.55 (0.06)