Table 2.
Discovery and Validation of genes associated with survival.
| Gene | Location | TCGA | TCC | Moffitt | |||
|---|---|---|---|---|---|---|---|
| HR | p value | HR | p value | FC* | p value | ||
| AURKA | 20q13 | 2.15 (1.59‐2.91) | 1.30E−06 | 2.42 (1.73‐3.37) | 2.38E−07 | 0.49 | 1.90E−9 |
| AURKB | 17p13.1 | 2.71 (2.00‐3.66) | 8.63E−10 | 1.50 (1.07‐2.08) | 1.68E−02 | 0.99 | 2.86E−11 |
| BIRC5 | 17q25 | 2.51 (1.85‐3.39) | 1.06E−08 | 1.69 (1.22‐2.36) | 1.70E−03 | 1.40 | 2.39E−14 |
| CCNE1 | 19q12 | 2.65 (1.96‐3.59) | 8.01E−10 | 1.89 (1.36‐2.64) | 1.53E−04 | 0.71 | 8.01E−09 |
| MKI67 | 10q26.2 | 1.65 (1.22‐2.23) | 1.29E−03 | 2.05 (1.47‐2.86) | 2.24E−05 | 1.13 | 7.41E−11 |
| MMP9 | 20q11.2‐q13.1 | 1.77 (1.31‐2.39) | 2.44E−04 | 1.49 (1.07‐2.07) | 1.78E−02 | 1.82 | 3.82E−09 |
| PLOD2 | 3q24 | 1.74 (1.29‐2.35) | 4.27E−04 | 2.99 (2.14‐4.17) | 2.31E−10 | 1.42 | 9.79E−10 |
| SAA1 | 11p15.1 | 2.47 (1.82‐3.34) | 1.64E−08 | 2.90 (2.08‐4.04) | 6.24E−10 | 3.52 | 1.01E−10 |
| TOP2A | 17q21‐q22 | 1.87 (1.38‐2.52) | 7.43E−05 | 2.10 (1.51‐2.92) | 1.19E−05 | 1.24 | 7.32E−14 |
*
Log 2‐fold change.