FIGURE 5.

Summary of relevant findings. A, Methylation analysis of 450 DNA damage response (DDR) genes revealed 17 functional DDR genes of which in seven genes hypomethylation showed association with reduced survival. Hypomethylation of PRPF19 and TP73 was associated with worse survival in patients with MGMT promoter unmethylated tumors with adjustment for tumor purity. TERT promoter mutations were correlated with methylation groups and survival times. B, PRPF19 and TERT k/d‐induced sensitivity in glioblastoma cells toward temozolomide but not radiotherapy. k/d, knock down; MGMT, unmethylated MGMT promoter; TMZ, temozolomide; RT, radiotherapy