Figure 6.

RES inhibits EMT and ECM caused by STAT3 activation. (A) HeLa cells and (B) SiHa cells were seeded in 6‐well plates at 1 × 10⁶ cells/well, cultured for 24 h and divided into four groups. Cells were treated with a vehicle in the control group. Cells were treated with IL‐6 in the IL‐6 treatment group; cells were treated with RES for 24 h in the resveratrol+IL‐6 group, and IL‐6 was added and incubated for another 24 h. Cells were treated with IL‐6 for 3 h in the IL‐6+ resveratrol group, and resveratrol was added and incubated for another 24 h. Cells were collected after treatment, and E‐cadherin, N‐cadherin, vimentin, MMP‐13, and MMP‐3 protein levels were determined through Western blot. The samples derived from the same experiment and the blots were processed in parallel. RES 40 mM; IL‐6, 50 μg/ml. Results were quantitatively analyzed. *, compared with the control, p < 0.05; #, compared with the IL‐6 group, p < 0.05; and^Δ, compared with the IL‐6+RES group, p < 0.05