Figure 7.

Pretreatment or treatment with RES inhibited the expression of EMT molecular markers and ECM degradation enzymes and the phosphorylation of STAT3 in cervical cancer tissues in the mouse model. (A) STAT3, p‐STAT3 (Tyr705), N‐cadherin, E‐cadherin, and vimentin in the tumor tissues grown from HeLa cells were determined through immunohistochemistry. Scale bar =20 μm. The results were quantitatively analyzed. *, p < 0.05. (B) p‐STAT3 (Tyr705), vimentin, MMP‐13, and MMP‐3 protein levels in the tumor tissues grown from HeLa cells were determined through Western blot. The samples derived from the same experiment and the blots were processed in parallel. The results were quantitatively analyzed. *, p < 0.05