FIGURE 5.

Univariate and multivariate logistic and Cox regression analysis to evaluate the independent effect of ITS on durable clinical benefit and survival outcomes (overall survival and progression‐free survival) in meta‐cohort. (A) Univariate and multivariate logistic regression analysis for durable clinical benefit. (B) Univariate and multivariate Cox proportional hazards regression analysis for overall survival. (C) Univariate and multivariate Cox proportional hazards regression model for progression‐free survival. The value of 1 represented positive, whereas 0 represented negative in Signature. The median value was taken as the cutoff of TMB. Meta‐cohort was composed of the Allen cohort, Snyder cohort, and Liu cohort. Data were adjusted by gender, M stage, LDH, TMB, mutational signatures and mutations in BRAF, NRAS, and NF1. LDH, lactate dehydrogenase; TMB, tumor mutation burden; ITS, immunotherapy score; OR, odds ratio; HR, hazard ratio; CI, confidence interval; Mut, mutation; Wt, wild type