TABLE 2.
Results of the univariate and multivariate survival analysis (Cox Proportional Hazard model) for the outcome disease‐specific survival on the Italian cohort (*P < .05)
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Age | 1.013 | 0.998‐1.029 | .080 | |||
| Gender | ||||||
| Female | 1 | 1 | ||||
| Male | 1.756 | 1.110‐2.780 | .016* | 1.695 | 1.026‐2.801 | .039* |
| Grade | ||||||
| G1 | 1 | .033* | 1 | .572 | ||
| G2 | 0.992 | 0.543‐1.180 | .978 | 0.702 | 0.362‐1.360 | .294 |
| G3 | 1.759 | 0.940‐3.291 | .077 | 0.715 | 0.339‐1.506 | .378 |
| 7th AJCC edition | ||||||
| Stage I | 1 | <.001* | 1 | .007* | ||
| Stage II | 1.995 | 0.997‐3.992 | .051 | 1.804 | 0.833‐3.907 | .134 |
| Stage III | 2.388 | 1.174‐4.857 | .016* | 1.397 | 0.602‐3.239 | .436 |
| Stage IV | 4.293 | 2.237‐8.236 | <.001* | 3.117 | 1.439‐6.750 | .004* |
| Perineural invasion | ||||||
| No | 1 | 1 | ||||
| Yes | 2.443 | 1.506‐3.964 | <.001* | 2.048 | 1.172‐3.581 | .012* |
| Immune‐phenotype | ||||||
| Inflamed | 1 | <.001* | 1 | <.001* | ||
| Excluded | 0.750 | 0.475‐1.185 | .218 | 0.884 | 0.540‐1.448 | .625 |
| Desert | 2.309 | 1.335‐3.995 | .003* | 2.673 | 1.497‐4.773 | .001* |
Abbreviation: AJCC, Americant Joint Committee on Cancer.