TABLE 3.
Results of the univariate and multivariate analysis (Cox Proportional Hazard model) for the outcomes Disease‐Free Survival on the Italian cohort (*P < .05)
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Age | 0.998 | 0.981‐1.015 | .788 | |||
| Gender | ||||||
| Female | 1 | 1 | ||||
| Male | 1.159 | 0.702‐1.913 | .565 | 1.030 | 0.601‐1.762 | .915 |
| Grade | ||||||
| G1 | 1 | .422 | 1 | .475 | ||
| G2 | 1.600 | 0.750‐3.415 | .224 | 1.668 | 0.732‐3.799 | .223 |
| G3 | 1.694 | 0.745‐3.857 | .209 | 1.531 | 0.598‐3.921 | .735 |
| 7th AJCC edition | ||||||
| Stage I | 1 | .700 | 1 | .964 | ||
| Stage II | 0.778 | 0.400‐1.513 | .459 | 0.943 | 0.453‐1.966 | .876 |
| Stage III | 1.143 | 0.593‐2.203 | .690 | 1.139 | 0.541‐2.396 | .732 |
| Stage IV | 1.085 | 0.563‐2.091 | .807 | 1.032 | 0.487‐2.185 | .935 |
| Perineural invasion | ||||||
| No | 1 | 1 | ||||
| Yes | 1.370 | 0.828‐2.266 | .220 | 1.242 | 0.694‐2.220 | .466 |
| Immune‐phenotype | ||||||
| Inflamed | 1 | .026* | 1 | .028* | ||
| Excluded | 0.956 | 0.563‐1.624 | .869 | 0.937 | 0.537‐1.635 | .819 |
| Desert | 2.241 | 1.139‐4.411 | .020* | 2.313 | 1.118‐4.786 | .024* |
Abbreviation: AJCC, Americant Joint Committee on Cancer.