TABLE 4.

Results from the multivariate analysis for the outcomes Disease‐Specific and Disease‐Free survival including only patients staged according to the 8th AJCC edition (*P < .05)

Variable	Multivariate analysis
	Disease‐specific survival			Disease‐free survival
	HR	95% CI	P‐value	HR	95% CI	P‐value
Gender
Female	1			1
Male	1.913	1.001‐3.655	0.050	1.276	0.648‐2.510	0.481
8th AJCC edition
Stage I	1		0.007*	1		0.614
Stage II	1.699	0.470‐6.140	0.419	0.615	0.228‐1.657	0.336
Stage III	3.013	0.882‐10.289	0.078	1.190	0.472‐3.003	0.713
Stage IV	5.101	1.712‐15.205	0.003*	0.851	0.363‐1.996	0.711
Perineural invasion
No	1			1
Yes	1.871	0.982‐3.565	0.057	1.341	0.672‐2.674	0.405
Immune‐phenotype
Inflamed	1		0.043*	1		0.026*
Excluded	0.932	0.509‐1.707	0.820	0.681	0.344‐1.346	0.269
Desert	2.280	1.107‐4.696	0.025*	2.146	0.941‐4.893	0.070

Abbreviation: AJCC, Americant Joint Committee on Cancer.