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. 2020 Oct 31;32(5):547–563. doi: 10.21147/j.issn.1000-9604.2020.05.01

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Copyright © 2020 Chinese Journal of Cancer Research. All rights reserved.

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SLC38A3 expression level correlated with several target therapeutic drugs. (A) Volcano plot displaying association between SLC38A3-loss and 251 pharmacologic inhibitors from GDSC study. X axis, Pearson correlation coefficient r; Y axis, significance −log ₁₀ P (P<0.05, r>0.4 or r<−0.4); (B) Heatmap showed IC₅₀ of SLC38A3 significantly correlated drugs in different ESCC cell lines. The ln (IC₅₀) data were used for z-score calculation. SLC38s, solute carrier family 38; GDSC, Genomics of Drug Sensitivity in Cancer database; IC₅₀, half inhibitory concentration; ESCC, esophageal squamous cell carcinoma.