1. Association of SLC38A3 CNV with clinicopathological features in integrated ESCC cohort.
| Clinicopathological features | Total [n (%)] | SLC38A3 CNV status [n (%)] | P | |
| Loss | Non-loss | |||
| SLC38s, solute carrier family 38; CNV, copy number variation; ESCC, esophageal squamous cell carcinoma; LNM, lymph node metastasis. | ||||
| Gender | 0.485 | |||
| Male | 42 (13.4) | 17 (40.5) | 25 (59.5) | |
| Female | 272 (86.6) | 95 (34.9) | 177 (65.1) | |
| Age (year) | 0.357 | |||
| ≤59 | 158 (50.8) | 52 (32.9) | 106 (67.1) | |
| >59 | 153 (49.2) | 58 (37.9) | 95 (62.1) | |
| LNM | 0.026 | |||
| Yes | 153 (48.7) | 64 (41.8) | 89 (58.2) | |
| No | 161 (51.3) | 48 (29.8) | 113 (70.2) | |
| N stage | 0.462 | |||
| N0+N1 | 79 (77.5) | 48 (60.8) | 31 (39.2) | |
| N2 | 23 (22.5) | 12 (52.2) | 11 (47.8) | |
| Grade | 0.225 | |||
| 1 | 100 (34.0) | 29 (29.0) | 71 (71.0) | |
| 2 | 146 (49.7) | 55 (37.7) | 91 (62.3) | |
| 3 | 48 (16.3) | 20 (41.7) | 28 (58.3) | |
| T stage | 0.603 | |||
| T1+T2 | 76 (24.2) | 29 (38.2) | 47 (61.8) | |
| T3+T4 | 238 (75.8) | 83 (34.9) | 155 (66.1) | |
| Smoking | 0.575 | |||
| Yes | 224 (75.9) | 77 (34.4) | 147 (65.6) | |
| No | 71 (24.1) | 27 (38.0) | 44 (62.0) | |
| Drinking | 0.002 | |||
| Yes | 83 (43.5) | 45 (54.2) | 38 (45.8) | |
| No | 108 (56.5) | 35 (32.4) | 73 (67.6) | |
| Pathological stage | 0.022 | |||
| I | 62 (21.0) | 13 (21.0) | 49 (79.0) | |
| II | 93 (31.5) | 35 (37.6) | 58 (62.4) | |
| III+IV | 140 (47.5) | 56 (40.0) | 84 (60.0) | |
| Overall survival | 0.016 | |||
| Dead | 141 (52.0) | 60 (42.6) | 81 (57.4) | |
| Alive | 130 (48.0) | 37 (28.5) | 93 (71.5) | |
| 5-year survival | 0.029 | |||
| Dead | 138 (50.9) | 58 (42.0) | 80 (58.0) | |
| Alive | 133 (49.1) | 39 (29.3) | 94 (70.7) | |