3. Multivariate Cox regression analysis of risk factors associated with OS and 5-year survival.

Risk factor	OS			5-year survival
	Adjusted HR (95% CI)	P		Adjusted HR (95% CI)	P
OS, overall survival; LNM, lymph node metastasis; SLC38, solute carrier family 38; HR, hazard ratio; 95% CI, 95% confidence interval.
Gender	1.245 (0.712−2.179)	0.442		1.198 (0.684−2.096)	0.528
Age	1.182 (0.732−1.906)	0.494		1.154 (0.712−1.868)	0.561
LNM	1.768 (1.093−2.859)	0.020		1.789 (1.101−2.907)	0.019
T stage (3/4 vs. 1/2)	2.381 (1.157−4.899)	0.018		2.621 (1.228−5.591)	0.013
Grade (2/3 vs. 1)	0.754 (0.439−1.297)	0.308		0.758 (0.440−1.305)	0.317
SLC38A3 low expression	1.799 (1.126−2.875)	0.014		1.796 (1.123−2.874)	0.015