S2. Prediction of functional effects of SLC38s family with somatic alterations in integrated ESCC cohort.
| Sample ID | Gene ID | Alteration* | Type** | Polyphen-2 |
| SLC38, solute carrier family 38; ESCC, esophageal squamous cell carcinoma; MISSENSE, missense mutation; TRUNC, truncating mutation; *, somatic genomic alteration; **, alteration type. | ||||
| ESCC-0082 | SLC38A1 | p.K213N | MISSENSE | POSSIBLY DAMAGING |
| ESCC-0432 | SLC38A1 | p.I327T | MISSENSE | BENIGN |
| ESCC-0467 | SLC38A1 | p.L433V | MISSENSE | POSSIBLY DAMAGING |
| ESCC-0171 | SLC38A2 | p.I365V | MISSENSE | BENIGN |
| ESCC-0008 | SLC38A2 | p.A343T | MISSENSE | POSSIBLY DAMAGING |
| ESCC-0304 | SLC38A2 | p.SN55fs | TRUNC | POSSIBLY DAMAGING |
| ESCC-0428 | SLC38A4 | p.R292H | MISSENSE | BENIGN |
| ESCC-0275 | SLC38A5 | p.F302L | MISSENSE | BENIGN |
| ESCC-0089 | SLC38A6 | p.D452H | MISSENSE | BENIGN |
| ESCC-0249 | SLC38A6 | p.D326H | MISSENSE | POSSIBLY DAMAGING |
| ESCC-0421 | SLC38A6 | p.L440F | MISSENSE | POSSIBLY DAMAGING |
| ESCC-0308 | SLC38A7 | p.V218I | MISSENSE | POSSIBLY DAMAGING |