S4. Sensitivities of significant SLC38A3 mRNA level associated drugs in ESCC cell lines.
| Cell
line name |
GSK319347A | TGX221 | Erlotinib | HG-5-
88-01 |
rTRAIL | OSI-930 | Bexarotene | IPA-3 | GSK690693 | FMK | PIK-93 | Motesanib | PAC-1 | Veliparib | Palbociclib |
| SLC38, solute carrier family 38; ESCC, esophageal squamous cell carcinoma; na, not available. | |||||||||||||||
| COLO-680N | na | na | na | na | 0.88 | 5.65 | 4.59 | 3.84 | 3.06 | 4.82 | 6.23 | 3.67 | 1.51 | 4.42 | 1.74 |
| EC-GI-10 | 4.07 | na | 2.72 | 3.91 | 0.19 | 4.39 | 4.60 | 5.49 | 5.04 | 5.71 | 2.73 | 2.29 | 3.66 | 4.30 | 1.01 |
| HCE-4 | na | na | na | na | na | 3.99 | 3.10 | 2.44 | 4.50 | 4.95 | 6.23 | na | na | na | na |
| KYSE-140 | na | na | na | 3.70 | na | 4.37 | 3.01 | 2.59 | 0.54 | na | 2.73 | 2.14 | 0.59 | 4.53 | 1.98 |
| KYSE-150 | na | na | na | 4.81 | −0.26 | 4.43 | 3.34 | 3.43 | 3.23 | 4.58 | 3.08 | 3.26 | 1.06 | 2.46 | −0.01 |
| KYSE-180 | na | na | na | na | −1.42 | 4.40 | 0.78 | 5.88 | 3.64 | 4.67 | 2.44 | na | 1.17 | na | na |
| KYSE-220 | na | na | na | 2.87 | 0.32 | 5.07 | 4.44 | 5.88 | 1.66 | 3.83 | 3.01 | 2.96 | 2.99 | 4.20 | 2.25 |
| KYSE-270 | na | na | na | na | −0.29 | 4.08 | 3.74 | 2.32 | 3.64 | 4.46 | 1.61 | na | 0.09 | na | na |
| KYSE-410 | na | na | na | 2.62 | −0.15 | 5.10 | 3.97 | 3.53 | 2.94 | 5.22 | 3.34 | 2.59 | 0.17 | 3.42 | −0.14 |
| KYSE-450 | na | na | na | 4.61 | −0.67 | 4.72 | 2.32 | 2.58 | 2.26 | 3.03 | 2.23 | 2.79 | 0.36 | 3.37 | 2.07 |
| KYSE-50 | na | na | na | 3.77 | −2.02 | 2.80 | 2.32 | 2.25 | 2.72 | 5.37 | 3.01 | 2.49 | 3.29 | 4.00 | 1.86 |
| KYSE-510 | na | na | na | na | −0.33 | 4.31 | 2.31 | 2.46 | 3.61 | 4.95 | 2.84 | 2.12 | 0.57 | 2.77 | 1.41 |
| KYSE-520 | na | na | na | na | 0.45 | 5.77 | 4.21 | 5.62 | 3.33 | 5.22 | 3.43 | 2.63 | 2.49 | 3.64 | 0.69 |
| KYSE-70 | na | na | na | na | −0.56 | 4.63 | 2.97 | 3.51 | 4.27 | 5.79 | 3.62 | na | 3.45 | 2.95 | na |
| OE21 | na | na | na | 2.50 | 0.42 | 5.25 | 2.86 | 3.30 | 3.84 | 5.66 | 3.57 | 3.03 | 0.81 | 3.51 | −0.08 |
| TE-1 | 3.10 | 3.07 | −1.40 | 1.07 | −2.45 | 3.90 | 3.19 | 6.74 | 5.56 | 6.17 | 5.49 | 3.96 | 4.18 | 4.87 | 4.66 |
| TE-10 | 4.05 | 3.75 | 1.25 | 3.05 | 0.05 | 3.61 | 3.42 | 3.17 | 4.78 | 5.24 | 4.25 | 3.24 | 3.01 | na | 1.75 |
| TE-11 | na | na | na | na | −0.81 | 4.17 | 3.56 | 4.94 | 4.58 | 5.15 | 4.22 | 3.05 | 2.11 | 3.24 | 1.48 |
| TE-12 | 3.82 | 3.63 | −2.62 | 2.57 | 0.30 | 3.50 | 2.22 | 6.60 | 3.85 | 6.11 | 3.68 | 3.34 | 4.05 | 4.60 | 3.33 |
| TE-15 | 4.48 | 5.11 | 0.96 | na | −0.01 | 3.54 | 3.30 | 2.46 | 2.49 | 3.51 | 1.99 | 3.45 | 1.70 | 4.58 | 1.43 |
| TE-4 | na | na | na | 3.19 | −1.80 | 4.01 | na | na | 3.04 | na | 4.88 | 2.42 | na | 4.19 | 1.92 |
| TE-5 | 4.53 | 4.90 | 0.55 | 2.60 | −0.90 | 4.91 | 2.53 | 4.19 | 3.37 | 5.51 | 4.42 | 3.34 | 3.81 | 4.23 | 1.48 |
| TE-6 | 4.34 | 4.54 | 0.18 | na | 0.41 | 4.18 | 4.03 | 3.38 | 3.54 | 6.25 | 3.70 | 2.81 | 3.50 | 4.86 | 1.93 |
| TE-8 | 4.40 | 4.19 | 1.81 | 4.91 | 0.24 | 3.96 | 2.54 | 3.56 | 4.84 | 5.67 | 3.07 | 3.42 | 2.86 | 4.39 | 0.06 |
| TE-9 | 4.30 | 2.30 | na | 2.64 | 0.00 | 4.37 | 2.73 | 2.94 | 4.94 | 5.44 | 5.79 | 3.41 | 3.31 | 4.41 | 3.01 |
| T-T | na | na | na | na | 0.16 | 4.33 | 1.20 | 4.72 | 4.89 | 5.53 | 2.54 | 2.81 | 3.10 | 3.92 | 1.03 |
| Pearson r | −0.84 | −0.73 | −0.73 | −0.55 | −0.54 | −0.45 | −0.44 | 0.41 | 0.44 | 0.45 | 0.46 | 0.50 | 0.51 | 0.54 | 0.68 |
| P | 0.00 | 0.03 | 0.04 | 0.03 | 0.01 | 0.02 | 0.03 | 0.04 | 0.02 | 0.03 | 0.02 | 0.02 | 0.01 | 0.01 | 0.00 |