2. Comparison of clinico-pathological data between different histological grades of TNBC.
| Variables | n (%) | P | n (%) | P | ||
| LG-cTNBC (n=85) | HG-cTNBC (n=344) | LG-TNBC (n=172) | HG-TNBC (n=410) | |||
| TNBC, triple negative breast cancer; cTNBC, conventional type of triple negative breast cancer; LG, low grade; HG, high grade; DCIS, ductal carcinomain situ; TIL, tumor infiltrating lymphocytes; *, categorical variables were analyzed by Chi-squared test or Fisher’s exact test, and continuous data were analyzed using the Student’st-test. | ||||||
| Age (year) [median (range)] | 55 (24−93) | 53 (24−92) | 0.096 | 59 (24−93) | 53 (24−92) | <0.001 |
| DCIS | ||||||
| Low | 5 (14.3) | 5 (4.2) | <0.001 | 18 (20.0) | 5 (3.6) | <0.001 |
| Middle | 24 (68.6) | 54 (45.0) | 59 (65.6) | 64 (45.7) | ||
| High | 6 (17.1) | 61 (50.8) | 13 (14.4) | 71 (50.7) | ||
| TILs | ||||||
| Little | 9 (32.1) | 50 (28.2) | 0.656 | 13 (26.5) | 56 (27.5) | 0.264 |
| Middle | 6 (21.4) | 29 (16.4) | 13 (26.5) | 34 (16.7) | ||
| Large | 13 (46.4) | 98 (55.4) | 23 (46.9) | 114 (55.9) | ||
| HER2 | ||||||
| 0 | 35 (41.7) | 169 (49.3) | 0.366 | 59 (34.7) | 207 (50.6) | <0.001 |
| 1+ | 32 (38.1) | 122 (35.6) | 67 (39.4) | 144 (35.2) | ||
| 2+ | 17 (20.2) | 52 (15.2) | 44 (25.9) | 58 (14.2) | ||
| AR (%) [median (range)] | 18 (0−90) | 8 (0−90) | 0.011 | 36 (0−90) | 10 (0−90) | <0.001 |
| Neoadjuvant therapy | 26 (31.7) | 141 (42.7) | 0.079 | 36 (21.8) | 154 (38.9) | <0.001 |
| Tumor regression score | ||||||
| G1 | 1 (3.7) | 26 (18.7) | 0.158* | 4 (11.1) | 28 (18.5) | 0.164* |
| G2 | 1 (3.7) | 17 (12.2) | 1 (2.8) | 20 (13.2) | ||
| G3 | 11 (40.7) | 38 (27.3) | 13 (36.1) | 41 (27.2) | ||
| G4 | 5 (18.5) | 19 (13.7) | 9 (25.0) | 22 (14.6) | ||
| G5 | 9 (33.3) | 39 (28.1) | 9 (25.0) | 40 (26.5) | ||
| Tumor size (cm) [median
(range)] |
1.90 (0.15−8.00) | 2.32 (0.20−14.00) | 0.133 | 1.96 (0.15−8.00) | 2.42 (0.20−14.00) | 0.005 |
| Grade | ||||||
| 1 | 1 (1.2) | 0 (0) | <0.001* | 23 (13.9) | 0 (0) | <0.001* |
| 2 | 80 (98.8) | 0 (0) | 143 (86.1) | 0 (0) | ||
| 3 | 0 (0) | 344 (100) | 0 (0) | 410 (100) | ||
| Score [median (range)] | 7 (5−7) | 8 (8−9) | <0.001 | 6 (3−7) | 8 (8−9) | <0.001 |
| Duct formation | ||||||
| 1 | 0 (0) | 0 (0) | <0.001* | 3 (1.8) | 0 (0) | <0.001* |
| 2 | 12 (15.4) | 0 (0) | 30 (18.4) | 0 (0) | ||
| 3 | 66 (84.6) | 341 (100) | 130 (79.8) | 406 (100) | ||
| Nuclear grade | ||||||
| 1 | 1 (1.3) | 0 (0) | <0.001* | 9 (5.5) | 0 (0) | <0.001* |
| 2 | 71 (91.0) | 162 (47.5) | 141 (86.5) | 188 (46.3) | ||
| 3 | 6 (7.7) | 179 (52.5) | 13 (8.0) | 218 (53.7) | ||
| Mitotic activity | ||||||
| 1 | 29 (37.2) | 0 (0) | <0.001* | 88 (54.0) | 0 (0) | <0.001* |
| 2 | 44 (56.4) | 20 (5.9) | 69 (42.3) | 30 (7.4) | ||
| 3 | 5 (6.4) | 321 (94.1) | 6 (3.7) | 376 (92.6) | ||
| Mitotic count [median (range)] | 9 (0−60) | 28 (2−100) | <0.001 | 7 (0−60) | 27 (2−100) | <0.001 |
| Ki67 (%) [median (range)] | 47 (8−95) | 74(0−95) | <0.001 | 36 (2−95) | 72 (0−95) | <0.001 |
| Sentinel lymph node
metastasis |
12 (30.8) | 40 (21.5) | 0.216 | 24 (27.3) | 46 (20.8) | 0.231 |
| Lymph node metastasis | 20 (52.6) | 72 (48.3) | 0.717 | 39 (53.4) | 86 (48.6) | 0.578 |
| TNM | ||||||
| 1 | 19 (36.5) | 86 (38.1) | 0.002* | 46 (38.3) | 101 (36.2) | 0.025 |
| 2 | 20 (38.5) | 87 (38.5) | 49 (40.8) | 105 (37.6) | ||
| 3 | 6 (11.5) | 3 (1.3) | 11 (9.2) | 11 (3.9) | ||
| 4 | 7 (13.5) | 50 (22.1) | 14 (11.7) | 62 (22.2) | ||
| Prognosis stage | ||||||
| 1 | 0 (0) | 0 (0) | 0.341* | 1 (0.8) | 0 (0) | 0.038* |
| 2 | 19 (36.5) | 87 (38.7) | 52 (43.3) | 102 (36.7) | ||
| 3 | 26 (50.0) | 88 (39.1) | 53 (44.2) | 114 (41.0) | ||
| 4 | 7 (13.5) | 50 (22.2) | 14 (11.7) | 62 (22.3) | ||
| T | ||||||
| 1 | 34 (65.4) | 124 (55.1) | 0.304 | 73 (60.8) | 146 (52.5) | 0.255* |
| 2 | 15 (28.8) | 85 (37.8) | 42 (35.0) | 108 (38.8) | ||
| 3 | 3 (5.8) | 9 (4.0) | 4 (3.3) | 15 (5.4) | ||
| 4 | 0 (0) | 7 (3.1) | 1 (0.8) | 9 (3.2) | ||
| N | ||||||
| 0 | 27 (52.9) | 149 (66.8) | 0.153* | 73 (61.3) | 182 (65.9) | 0.806* |
| 1 | 19 (37.3) | 64 (28.7) | 37 (31.1) | 77 (27.9) | ||
| 2 | 1 (2.0) | 4 (1.8) | 3 (2.5) | 7 (2.5) | ||
| 3 | 4 (7.8) | 6 (2.7) | 6 (5.0) | 10 (3.6) | ||
| M | ||||||
| 0 | 46 (86.8) | 176 (75.5) | 0.099 | 106 (86.2) | 217 (75.6) | 0.018 |
| 1 | 7 (13.2) | 57 (24.5) | 17 (13.8) | 70 (24.4) | ||