2. Factors associated with PFS and OS.

Variables	PFS					OS
	Univariate		Multivariate			Univariate		Multivariate
	HR (95% CI)	P	HR (95% CI)	P		HR (95% CI)	P	HR (95% CI)	P
PFS, progression-free survival; OS, overall survival; NLR, neutrophil-to-lymphocyte ratio; ECOG PS, Eastern Cooperative Oncology Group performance status; TTP, time-to-progression; gMDSC, granulocytic myeloid-derived suppressor cell; mMDSC, monocytic myeloid-derived suppressor cell; 95% CI, 95% confidence interval; HR, hazard ratio.
NLR≥2.94	1.77 (1.13−2.77)	0.012	1.58 (1.01−2.49)	0.046		2.18 (1.32−3.60)	0.002	1.77 (1.04−3.04)	0.036
Age	1.00 (0.98−1.02)	0.903	−	−		0.99 (0.97−1.02)	0.610	0.98 (0.96−1.01)	0.136
Male gender	0.93 (0.62−1.41)	0.735	−	−		0.77 (0.48−1.23)	0.278	−	−
ECOG PS 2	1.12 (0.76−1.65)	0.558	−	−		1.46 (0.98−2.18)	0.062	1.56 (1.04−2.34)	0.034
First-line TTP<6 months	2.11 (1.39−3.20)	<0.001	1.99 (1.31−3.05)	0.001		2.21 (1.38−3.54)	0.001	1.99 (1.20−3.29)	0.008
Hemoglobin <10 g/dL	1.67 (1.05−2.67)	0.031	−	−		2.05 (1.19−3.53)	0.010	1.74 (0.98−3.08)	0.057
gMDSC count	1.00 (0.99−1.00)	0.705	−	−		1.00 (1.00−1.00)	0.128	−	−
mMDSC count	1.00 (0.99−1.00)	0.367	−	−		1.00 (1.00−1.00)	0.044	−	−