Table 2.
Clinical Characteristics of Patients with a High (≥125) and Low (<125) FAR
| Characteristics | High FAR (≥125) (n = 66) | Low FAR (<125) (n = 91) | p Value |
|---|---|---|---|
| Age in years | 54.95 ± 13.89 | 57.53 ± 14.05 | 0.26 |
| Gender n (%) | 0.45 | ||
| Male | 48 (72.73) | 61 (67.03) | |
| Female | 18 (27.27) | 30 (32.97) | |
| Comorbidities n (%) | |||
| Diabetes mellitus | 24 (36.92) | 31 (34.07) | 0.71 |
| Hypertension | 47 (72.31) | 50 (54.95) | 0.03 |
| Coronary artery disease | 23 (34.85) | 32 (35.16) | 0.97 |
| Peripheral vascular disease | 1 (1.52) | 4 (4.40) | 0.31 |
| Atrial fibrillation | 8 (12.12) | 22 (24.18) | 0.06 |
| COPD | 2 (3.03) | 8 (8.79) | 0.15 |
| Laboratory values (25–75% IQ) | |||
| Hemoglobin (g/dl) | 9.9 (8.7–12.2) | 9.8 (8.5–11.8) | 0.99 |
| Platelet (×1,000/μl) | 149 (104–231) | 131 (94–220) | 0.18 |
| Mean platelet volume (fl) | 10.8 (10.4–12) | 10.5 (9.4–11.4) | 0.004 |
| Baseline creatinine (mg/dl) | 1.6 (1–2.4) | 1.25 (0.9–1.85) | 0.03 |
| GFR (ml/min/1.73 m2) | 39 (19–74) | 46 (29–68) | 0.23 |
| Lactic acid (mmol/L) | 7.6 (3.3–11.1) | 7.5 (4.2–12.3) | 0.53 |
| Fibrinogen (mg/dl) | 451 (373–563) | 242 (197–303) | <0.001 |
| Albumin (g/dl) | 2.4 (2.1–2.6) | 2.65 (2.3–3) | <0.001 |
| 24 hour PTT (seconds) | 58.7 (51.5–67.8) | 57.65 (44.4–65.4) | 0.14 |
| 48 hour PTT (seconds) | 56.25 (45.15–64.8) | 52.45 (41.75–62.4) | 0.12 |
| Indication for VA ECMO n (%) | 0.20 | ||
| Graft failure after OHT | 3 (4.55) | 14 (15.38) | |
| Acute myocardial infarction | 17 (25.76) | 25 (27.47) | |
| Postcardiotomy shock | 21(31.82) | 28 (30.77) | |
| Cardiomyopathy | 16 (24.24) | 13 (14.29) | |
| Respiratory failure | 5 (7.58) | 9 (9.89) | |
| Sepsis | 3 (4.55) | 2 (2.2) | |
| Cardiac arrest | 1 (1.52) | 0 | |
| Intra-aortic balloon pump n (%) | 24 (36.36) | 37 (40.66) | 0.59 |
| Impella n (%) | 6 (9.09) | 4 (4.49) | 0.25 |
| Total VA ECMO duration in hours (25–75% IQ) | 119 (81–167) | 95 (57–152) | 0.09 |
| Intracardiac or aortic root thrombi during VA | 4 (6.06) | 11 (12.64) | 0.24 |
| ECMO support n (%) | |||
| Survival at discharge n (%) | 22 (33.85) | 44 (48.89) | 0.06 |
FAR, fibrinogen albumin ratio; COPD =chronic obstructive pulmonary disease; PTT= partial thromboplastin time; VA ECMO = venoarterial extracorporeal membrane oxygenation; OHT =orthotopic heart transplant