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. 2020 Jul 16;87(6):E680–E688. doi: 10.1093/neuros/nyaa301

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Copyright © 2020 by the Congress of Neurological Surgeons

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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FIGURE 4. — Immunohistochemical analysis of DIPG xenografts treated with EPZ-6438. A, Images of representative Ki-67 and TUNEL staining of intracranial tumor from mice euthanized at the end of treatment. Mean and standard deviation (SD) values represent the average number of positive cells in 3 high-powered fields for each tumor. Statistical analysis was performed ANOVA with Tukey's multiple comparison. Ki-67: CED DMSO vs CED EPZ-6438, ****P < .0001, TUNEL: DMSO CED vs EPZ-6438 CED, ****P < .0001. B, Representative histological changes around the intratumor injection site upon EPZ-6438 administration by CED (left: hematoxylin and eosin (HE) staining, right: TUNEL staining). Black arrow, inflammatory cell infiltration.