TABLE 1.
Characteristics of the included studies and the exposures analyzed based on retrieved data
| Reference of the original publication | Study design | Population | Method used for TL | Exposure/Med Score | Variables included/considered in the MVA | QA |
|---|---|---|---|---|---|---|
| Boccardi et al., 2013 (30) | Cross-sectional | 217 (47% women) elderly Italian subjects, aged 71–87 y | PBL/qPCR Cawthon 2002 (42) | Trichopoulou 2003 (3) | Age, sex, inflammation, smoking habit | Good |
| Crous-Bou et al., 2014 (31) | Cross-sectional | 4676 healthy American women within the Nurses’ Health Study (NHS), aged 30–55 y | PBL/qPCR Cawthon 2002 (42) | Trichopoulou 2003 (3) | Age, BMI, pack-years of smoking, physical activity, total caloric intake | Good |
| Gu et al., 2015 (32) | Cross-sectional | 1743 (68% women) American multiethnic community, Washington Heights-Inwood Community Aging Project (WHICAP) study, aged >65 y | PBL/qPCR Cawthon 2009 (41) | Trichopoulou 2003 (3) | Age, sex, total energy intake, BMI, physical activity, smoking status, diabetes status, hypertensive status, dyslipidemia status, group of intervention (EVOO, nuts, Control) | Good |
| García-Calzón et al., 2016 (13) | Cross-sectional1 | 520 (54.8% women) Spanish individuals at high cardiovascular disease risk, PREDIMED-Navarra study, aged 55–80 y | PBL/qPCR Cawthon 2002 (42) | MEDAS score (38) | Age, sex, education, race/ethnicity (white, black, Hispanics), total caloric intake | Good |
| Leung et al., 2018 (33) | Cross-sectional | 4758 (53.6% women) American healthy nonelderly adults from the NHANES study, aged 20–65 y | Whole blood/qPCR Cawthon 2002 (42) | Panagiotakos 2007 (39) | Age, sex, race/ethnicity, educational attainment, marital status, poverty income ratio, alcohol consumption, smoking status, pack years of smoking, physical activity, change in activity over the past year, and total caloric intake | Good |
| Milte et al., 2018 (34) | Cross-sectional | 679 (52.6% women) Australian individuals from the Wellbeing, Eating and Exercise for a Long Life (WELL) study, aged 57–68 y | Whole blood /qPCR Cawthon 2002 (42) | Trichopoulou 2005 (37) | Age, sex, education, smoking, physical activity, BMI | Good |
| Meinilä et al., 2019 (35) | Cross-sectional2 | 1046 (56.4% women) Finnish individuals from the Helsinki Birth Cohort (HBC) study, aged 56–70 y | Whole blood /qPCR Cawthon 2009 (41) | Trichopoulou 2005 (37) | Age, sex, smoking, total caloric intake, BMI, educational attainment, and leisure-time physical activity | Good |
| Ventura et al., 2019 (36) | Cross-sectional | 94 (57.4% women) healthy adults, West Virginia, (USA), aged 45–64 y | PBMC/qPCR Cawthon 2002 (42) | Trichopoulou 2003 (3) | Age, sex, Life's Simple 7 (a tool estimating the cardiovascular health, continuous scale), smoking history, yearly income | Good |
1
Also included results from a randomized clinical trial.
2
Also included results from a prospective study. EVOO, extra-virgin olive oil; MEDAS, Mediterranean Diet Adherence Screener; MVA, multivariable adjusted model; PBL, peripheral blood leukocytes; PMBC, peripheral blood mononuclear cell; PREDIMED, Prevention with Mediterranean Diet; QA, quality assessment; TL, telomere length.